Tissue deposition of the insect repellent DEET and the sunscreen oxybenzone from repeated topical skin applications in rats.
Identifieur interne : 001982 ( Main/Exploration ); précédent : 001981; suivant : 001983Tissue deposition of the insect repellent DEET and the sunscreen oxybenzone from repeated topical skin applications in rats.
Auteurs : Daryl J. Fediuk [Canada] ; Tao Wang ; Joshua E. Raizman ; Fiona E. Parkinson ; Xiaochen GuSource :
- International journal of toxicology [ 1092-874X ] ; 2010.
English descriptors
- KwdEn :
- Administration, Topical, Animals, Astrocytes (drug effects), Behavior, Animal (drug effects), Benzophenones (administration & dosage), Benzophenones (blood), Benzophenones (pharmacokinetics), Benzophenones (toxicity), Cell Survival (drug effects), Cells, Cultured, DEET (administration & dosage), DEET (blood), DEET (pharmacokinetics), DEET (toxicity), Drug Synergism, Female, Fetus (cytology), Half-Life, Insect Repellents (administration & dosage), Insect Repellents (blood), Insect Repellents (pharmacokinetics), Insect Repellents (toxicity), Male, Neurons (drug effects), Permeability (drug effects), Random Allocation, Rats, Rats, Sprague-Dawley, Skin (drug effects), Skin (metabolism), Sunscreening Agents (administration & dosage), Sunscreening Agents (pharmacokinetics), Sunscreening Agents (toxicity), Tissue Distribution.
- MESH :
- chemical , administration & dosage : Benzophenones, DEET, Insect Repellents, Sunscreening Agents.
- chemical , blood : Benzophenones, DEET, Insect Repellents.
- cytology : Fetus.
- drug effects : Astrocytes, Behavior, Animal, Cell Survival, Neurons, Permeability, Skin.
- metabolism : Skin.
- chemical , pharmacokinetics : Benzophenones, DEET, Insect Repellents, Sunscreening Agents.
- chemical , toxicity : Benzophenones, DEET, Insect Repellents, Sunscreening Agents.
- Administration, Topical, Animals, Cells, Cultured, Drug Synergism, Female, Half-Life, Male, Random Allocation, Rats, Rats, Sprague-Dawley, Tissue Distribution.
Abstract
Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone are capable of enhancing skin permeation of each other when applied simultaneously. We carried out a cellular study in rat astrocytes and neurons to assess cell toxicity of DEET and oxybenzone and a 30-day study in Sprague-Dawley rats to characterize skin permeation and tissue disposition of the compounds. Cellular toxicity occurred at 1 µg/mL for neurons and 7-day treatment for astrocytes and neurons. DEET and oxybenzone permeated across the skin to accumulate in blood, liver, and brain after repeated topical applications. DEET disappeared from the application site faster than oxybenzone. Combined application enhanced the disposition of DEET in liver. No overt sign of behavioral toxicity was observed from several behavioral testing protocols. It was concluded that despite measurable disposition of the study compounds in vivo, there was no evidence of neurotoxicological deficits from repeated topical applications of DEET, oxybenzone, or both.
DOI: 10.1177/1091581810380147
PubMed: 20959613
Affiliations:
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Le document en format XML
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Fediuk</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. xgu@cc.umanitoba.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name></author><author><name sortKey="Raizman, Joshua E" sort="Raizman, Joshua E" uniqKey="Raizman J" first="Joshua E" last="Raizman">Joshua E. Raizman</name></author><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></author><author><name sortKey="Gu, Xiaochen" sort="Gu, Xiaochen" uniqKey="Gu X" first="Xiaochen" last="Gu">Xiaochen Gu</name></author></analytic><series><title level="j">International journal of toxicology</title><idno type="eISSN">1092-874X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Astrocytes (drug effects)</term><term>Behavior, Animal (drug effects)</term><term>Benzophenones (administration & dosage)</term><term>Benzophenones (blood)</term><term>Benzophenones (pharmacokinetics)</term><term>Benzophenones (toxicity)</term><term>Cell Survival (drug effects)</term><term>Cells, Cultured</term><term>DEET (administration & dosage)</term><term>DEET (blood)</term><term>DEET (pharmacokinetics)</term><term>DEET (toxicity)</term><term>Drug Synergism</term><term>Female</term><term>Fetus (cytology)</term><term>Half-Life</term><term>Insect Repellents (administration & dosage)</term><term>Insect Repellents (blood)</term><term>Insect Repellents (pharmacokinetics)</term><term>Insect Repellents (toxicity)</term><term>Male</term><term>Neurons (drug effects)</term><term>Permeability (drug effects)</term><term>Random Allocation</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Skin (drug effects)</term><term>Skin (metabolism)</term><term>Sunscreening Agents (administration & dosage)</term><term>Sunscreening Agents (pharmacokinetics)</term><term>Sunscreening Agents (toxicity)</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Benzophenones</term><term>DEET</term><term>Insect Repellents</term><term>Sunscreening Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Benzophenones</term><term>DEET</term><term>Insect Repellents</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Fetus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Astrocytes</term><term>Behavior, Animal</term><term>Cell Survival</term><term>Neurons</term><term>Permeability</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Benzophenones</term><term>DEET</term><term>Insect Repellents</term><term>Sunscreening Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Benzophenones</term><term>DEET</term><term>Insect Repellents</term><term>Sunscreening Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Cells, Cultured</term><term>Drug Synergism</term><term>Female</term><term>Half-Life</term><term>Male</term><term>Random Allocation</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone are capable of enhancing skin permeation of each other when applied simultaneously. We carried out a cellular study in rat astrocytes and neurons to assess cell toxicity of DEET and oxybenzone and a 30-day study in Sprague-Dawley rats to characterize skin permeation and tissue disposition of the compounds. Cellular toxicity occurred at 1 µg/mL for neurons and 7-day treatment for astrocytes and neurons. DEET and oxybenzone permeated across the skin to accumulate in blood, liver, and brain after repeated topical applications. DEET disappeared from the application site faster than oxybenzone. Combined application enhanced the disposition of DEET in liver. No overt sign of behavioral toxicity was observed from several behavioral testing protocols. It was concluded that despite measurable disposition of the study compounds in vivo, there was no evidence of neurotoxicological deficits from repeated topical applications of DEET, oxybenzone, or both.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Gu, Xiaochen" sort="Gu, Xiaochen" uniqKey="Gu X" first="Xiaochen" last="Gu">Xiaochen Gu</name><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><name sortKey="Raizman, Joshua E" sort="Raizman, Joshua E" uniqKey="Raizman J" first="Joshua E" last="Raizman">Joshua E. Raizman</name><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name></noCountry><country name="Canada"><region name="Manitoba"><name sortKey="Fediuk, Daryl J" sort="Fediuk, Daryl J" uniqKey="Fediuk D" first="Daryl J" last="Fediuk">Daryl J. Fediuk</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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